Welcome to the research pages for Biomedical Sciences at Royal Holloway, University of London. The Centre’s focus is on fundamental and applied research into the molecular mechanisms of disease. Research activities are concentrated around three main themes: Microbiology, Infection & Immunity; Regenerative Molecular Medicine; Molecular Neuroscience. Using model organisms ranging from bacterial and tissue cultures to dictyostelium, zebrafish and mouse, centre members test biological hypotheses that are relevant for a wide range of human and animal diseases. The Centre has research links within the Swan alliance and other universities in the greater London area, as well as across the UK, Europe and beyond, including USA, China, Vietnam, Australia, Mexico and Uruguay. Partners include members of the academic, government and industrial sectors.

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Cellular and Molecular Pharmacology. Identifying and understanding the molecular targets of the bipolar disorder/epilepsy/migraine treatment, Valproic acid, using the simple biomedical model, Dictyostelium, and mammalian cell systems. Analysing the relationship between drug structure, molecular target specificity and potential therapeutic function.

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Signalling events that influence the connectivity in the mammalian cortex. Study of mechanisms that mediate cell-cell communication by a variety of techniques.

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Regulation of stem cell quiescence and activation; the role of the niche in stem cell behaviour during degeneration and regeneration; cell fate choice - differentiation or self renewal; maintaining the capacity for effective adult muscle repair.

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The molecular mechanisms that control synapse development; the role of cell surface adhesion molecules in synaptogenesis and synaptic plasticity; the molecular architecture and functions of the post synaptic density; the role of homeobox genes and BMPs in neuronal regeneration.

BSc, PhD Lond

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Molecular Pharmacology of N-Methyl-D-aspartate glutamate receptors

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Control of transcription and development in Bacillus subtilis.  Role of checkpoints in coordinating gene expression with morphogenesis.  Development of edible vaccines.

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Biology and biochemistry of skeletal muscle. Development of genetically-engineered virus strains and proteolipid particles for gene therapy of neuromuscular and cardiovascular disease.  Production and analysis of transgenic mice as models for the pathogenesis and therapy of human diseases.

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Genetic, cellular and molecular mechanisms involved in the formation and patterning of the mammalian brain and spinal cord. Identification of mutations causing neural tube defects.

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Role of heparin and heparan sulphate polysaccharides in cytokine and interleukin signalling.

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Development and use of high throughput proteomics-based approaches for protein expression profiling. Neurobiology. Forensics.

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Secondary loss of mitochondrial function in parasitic protozoa and characterisation of remnant organelles using genomic and protoeomic approaches; study of critical signal transducing molecules during parasite differentiation using Entamoeba histolytica and Giardia intestinalis as model systems.

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Role of centrosomes in vertebrate development

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Gene therapy and neurogenesis in the central nervous system. Gene repair by homologous recombination. Lentiviral vectors.

To access publications by individual members of staff please go to "Staff" web pages